Research Scientist- Cell Therapy

  • Negotiable
  • Alameda, California
  • Biotech and Pharma

CSG Talent is working with a clinical-stage biotechnology company developing NK and NK-like gamma delta T
cell therapies using our patented ACC (Antibody Cell-Conjugation) technology platform. Using ACC
technology, they arm immune cells with antibodies to target and eradicate cancer cells. Their mission is to
develop safe, effective, and affordable cell therapies to fight and beat cancers.

Their platforms and products aim to address and overcome the major obstacles in cancer therapy: Ability to target low expression of tumor antigens to better prevent tumor escape; Trafficking of effector cells to tumor locations; Activate the immune system to attack cancer cells.

About the role

We are seeking a highly motivated scientist with strong interest in developing novel ACC-based
cancer therapies. This position will play an important role in research and pipeline development, IND
enabling, pharmacokinetic and pharmacodynamic analyses of clinical trials and contract research
organization (CRO) management. You will work and You will work in a supportive team, and collaborate
and communicate closely with clinical team and quality assurance team.

Position Title: Research Scientist
Location: Alameda, CA
Reports to: Director of Research and Development
Job Type: Full-time

Education /Background
* PhD in life science-related fields (Immunology, Molecular Biology, Pharmacology, Chemistry,
and Biochemistry) or Master's with 6+ years in science-related fields
* 2+ years of experience in cancer therapy research (cell therapy-related experience is a plus)
Responsibilities include, but are not limited to
* Perform primary T cell expansion to ACC-based cell products for pipeline development and
platform optimization
* Execute cytokine ELISA analysis, cytotoxicity assay and marker profiling for IND filing
* Conduct primary T cell transduction using virus-based or electroporation-based systems
* Search literature to design and set up in vitro cytotoxicity models and in vivo xenograft mouse
models to evaluate/initiate pipeline development
* Execute xenograft mouse studies with CROs using SCID-Beige, NSG, or humanized NSG mouse
models, and organize and interpret the data of bioluminescence and survival rate for presentation
* Manage CROs to ensure the assay development of flow cytometry-, ddPCR- or ELISA-based
analyses timely for translational studies of clinical trials.
* Organize translational study plan and provide scientific supports for clinical team
Position Requirements & Experience Relevant Skills & Experience:
* Mammalian cell culture, cytotoxicity analysis and multi-color fluorescence flow cytometry
experience in a laboratory setting are required
* Immunology background/knowledge is a plus
* Experience in primary T cell expansion/function is a plus
* Communication skills for CRO/vendor communication/management
* Writing skills and slide preparation for scientific document/presentation and official report
* Organization/coordination skills to prioritize the assignments to deliver results timely
* Follow SOPs & lab guidelines and be able to work independently
* Execute laboratory quality procedures and experiments with detail to attention
* Record experimental procedures, observation, and analyze data accurately
* Self-motivated in a fast-moving team environment
* Good team player and get along well with colleagues

Lexie Stratford Principal Consultant - Precision Medicine
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